During the period of adolescence, individuals are in the process of developing an identity for themselves, which involves taking risks and exploring the world for new perspectives. Substance use among adolescents stems from peer pressure, the need for an outlet from stressors related to family, school, or personal problems, and yearning to experience new things. Commonly, marijuana is the most prevalent illicit drug used in America according to the National Institute on Drug Abuse. Attention deficit hyperactivity disorder (ADHD) affects approximately nine percent of children between the ages of 13 to 19 according to National Institute on Mental Health. Characteristics of ADHD involve a consistent pattern of hyperactivity, impulsivity, and inattention that affects an individual’s ability to function in at least two settings (e.g., home & school). This study aims to explore the relationship between ADHD hyperactivity and inattention symptoms with the amount of marijuana use among high school sophomores. A sample (N=29) of high school sophomore students ages 15 to 17 years from rural and urban Iowa high schools was selected to participate in this study. Students were tasked with the completion of a semi-structured interview conducted within their households or private space. Results indicated that marijuana use and ADHD inattention symptoms were not related in a statistically significant manner. However, as students increase their marijuana usage, the more likely they were to display symptoms of ADHD hyperactivity. The relation between ADHD hyperactivity symptoms and marijuana use was statistically significant.