Advances in diagnostic medicine have led to an awareness and heightened concern for the high prevalence of amyloid-associated neurodegenerative diseases, especially in the elderly. Extraneous misfolded protein aggregates known as amyloids are ubiquitous in many neurodegenerative diseases and have been suggested to appear before clinical symptoms manifest, as in the case of Alzheimer's Disease (AD). Probes for monitoring aggregation of amyloid beta (Aβ) peptides are crucial to advance understanding of the molecular pathogenesis of AD. Photoactive transition metal complexes (TMCs) have received a great deal of attention for their potential as bio-sensors. The judicious choice of metal ions and ligands leads to luminescent compounds, which show great photo- and electro-chemical stability, high photoluminescence quantum yields, tunable emission color across the visible electromagnetic spectrum, and long-lived emissive excited states. Luminescent platinum complexes particularly have attractive chemical and photophysical properties which are advantageously used as labels for bio-imaging applications. The objective is to develop and synthesize platinum complexes based on bidentate Acetylacetone (ACAC) cyclometalated ligands as well as to design efficient routes leading to a collection of ACAC-amino acids ligands that will increase the solubility in water of the platinum complexes molecules. The design, synthesis, and applications of various efficient routes leading to a collection of ACAC ligands would potentially serve as probes for monitoring aggregation of amyloid beta (Aβ) peptides in Alzheimer’s Disease. Additional modification of cyclometalated platinum complexes will lead to new luminescent organometallic sensors with potential applications as novel bio-imaging agents for the detection of Alzheimer’s Disease.