Stathmin family members are ubiquitous cytosolic phosphoproteins found in cells throughout the body, including neurons. Stathmins play important roles in a number of cellular functions, including cell division, cell differentiation, and depolymerization of microtubules. In the nervous system, four members of the stathmin family are highly expressed with varied functions. For example, postnatal neurogenesis in the dentate gyrus of the hippocampus is reduced in stathmin-deficient mice, by virtue of its function to control the transition from dividing neuronal precursor to postmitotic neuron. Stathmin-deficient mice also develop abnormalities in both central and peripheral nervous system axons. The new P7C3-series of neuroprotective compounds have been recently shown to block axonal degeneration preceding cell death in both the central and peripheral nervous system, as well as to enhance neurogenesis by protecting newborn neural stem cells from death. Based on previous unbiased 2D gel proteomic analysis in our laboratory, we have discovered that P7C3 compounds affect expression levels of stathmin 1. We have thus sought to investigate whether the P7C3-series of compounds affects stathmin expression levels in the nervous system. Specifically, we investigated whether two potent and efficacious members of the P7C3 series, P7C3-A20 and P7C3-S321, affect expression levels of the stathmin family of proteins in PC6 cells. PC6 cells undergo differentiation into neuronal phenotype in response to exposure to nerve growth factor (NGF), and here we compared the effects of exposure of these cells to P7C3 compounds vs. NGF.