Mentor
Daniel Tranel, Neurology
Participation year
2015
Project title

Age and relational memory: Evaluating differences in relational memory performance in healthy young an older adults with explicit and implicit measures

Abstract

Relational memory is memory for the association between two arbitrarily-related stimuli (such as the name belonging to a face) and this type of memory depends upon the brain structures of the medial temporal lobe, especially the hippocampus. Hippocampal volume is known to decrease with age, and these age-related changes in the volume of the hippocampus would be expected to affect relational memory performance.  Specifically, we predicted that with aging, relational memory performance will decline whether measured explicitly or implicitly. In order to test this prediction, we adapted a previously published task shown to test hippocampus-dependent relational memory (Hannula et al. 2007), and we recruited two groups of healthy adults: young (age 18-22; N=10; and old (age 50-70; N=19). In the task, participants were instructed to study and remember a set of face-scene pairs. After three study phases showing the same face-scene pairs, participants were then tested on their memory for the face-scene pairs using a three-alternative, forced-choice recognition task coupled with a match-detection task (half of all test displays did not contain a studied face-scene pair). This task tested participants’ relational memory performance in two ways:  1) by recording their overt responses (an explicit memory measure); and 2) by recording their eye-movements (an implicit memory measure) throughout their decision-making process. Based on these data, we were able to determine the accuracy of participants’ match/non match decisions; evaluate their relational recognition memory performance; and observe the differences in eye-movements to selected matching faces (correct responses) versus selected non-matching faces (incorrect responses). The novelty of our project lies in studying age-related differences using a unique paradigm to measure relational memory both implicitly and explicitly. If our predictions are accurate, our findings would demonstrate a link between age and relational memory deficits suggestive of reductions in hippocampal volume. Future work will follow up on this investigation by explicitly studying the relationship between individual differences in the hippocampal volume of older adults and relational memory performance.

Kevin Selden
Education
Virginia State Univ