Lewy Body Dementia affects more than 1 million individuals nationwide. It is a slow, progressive cognitive disease that is characterized by abnormal protein deposits, called Lewy bodies, that may disrupt brain functioning. Lewy bodies are made up of alpha-synuclein, a protein that forms into clumps in neurons. It is thought that these aggregates cause neurons to not function properly, and in some neuron types, like dopaminergic cells, they may die. These proteins are typically found within the brainstem and other areas of the brain, however in patients with Lewy Body Dementia, alpha-synuclein is also found in the cortex. For this project, a virus coding for the expression of human alpha-synuclein was injected into the medial prefrontal cortexes of mice to determine its impact on cognitive functioning. The novel object recognition test was used to examine short-term memory and long-term memory. Mice were placed in an apparatus with two of the same objects for ten minutes, and then placed in an apparatus with one old object and one novel object. The duration of time the mouse interacted with the novel or old object for the full ten minutes was recorded. A video editing application was used to mark the start and end timepoints of each interaction. The time points were inputted in an excel file where a formula was used to convert the minute-second-frame format to total time spent with the object. The type of object (left or right) was inputted as well. The data was analyzed by a t-test through the use of a preference score(amount of time spent with one object subtracted by amount of time spent with the other object divided by total amount of time).The results indicated no significant difference in interaction times. However, the synuclein mice do interact with both objects less in the first 3 minutes.