Treatment efforts towards cocaine addiction are hampered by high relapse rates, and an understanding of neural circuitry underlying drug-seeking behaviors may inform treatment development. Studies have indicated that the prelimbic (PL) and infralimbic (IL) cortices are involved in cocaine-seeking behaviors in a rodent model of relapse. These regions are involved in learning and motivated behaviors, including those that require inhibitory control over behavior. In a recent study, the PL and IL showed increased Fos expression, a neural activation marker, following inhibitory control of cocaine seeking, but much remains unknown about their roles during self-administration. The standard cocaine self-administration task does not require rats to withhold responding, and thus it is unlikely to require these brain regions during cocaine self-administration.