Cancer is a debilitating disease that results in long-term physical impairment and psychological distress. In this study, we examined the effects of three coping styles (instrumental coping, palliative coping and avoidant coping) and positive/negative affect on physical functioning and symptom interference in everyday life among 88 cancer patients. Participants completed study measures at baseline, and at 6 month and 1 year post-treatment. Results suggest that negative coping predicts reduced physical functioning and increased symptom interference. Additionally, negative affect is a strong predictor of physical functioning and interference at both follow-up times points.