The intranasal route is an attractive site for drug delivery. Nanoparticles may provide unique therapeutic opportunities when included in nasal drug delivery systems. Solid lipid nanoparticles (SLNs) of two sizes, 30 and 150 nm, were synthesized and their uptake was investigated in the nasal tissues. Our uptake studies showed that the uptake of 150 nm SLNs was limited. On the other hand, we found that the uptake of smaller SLNs (30 nm) was more optimistic as a drug delivery vehicle since they can pass through the intercellular spaces of the nasal mucosa by delivering loaded drug moieties into the olfactory bulb region of the brain.